A|B|C|D|E|F|G|H|I|J|K|L|M|N|O|P|Q|R|S|T|U|V|W|X|Y|Z

Renovascular Conditions

Renovascular hypertension (or "renal hypertension") is a syndrome which consists of high blood pressure caused by narrowing of the arteries supplying the kidneys (renal artery stenosis). It is a form of secondary hypertension - a form of hypertension whose cause is identifiable.

Learn more:

SYMPTOMS

Most cases of renal artery stenosis are asymptomatic, and the main problem is high blood pressure that cannot be controlled with medication. Deterioration in renal function may develop if both kidneys are poorly supplied, or when treatment with an ACE inhibitor is initiated. Some patients present with episodes of flash pulmonary edema (sudden left ventricular heart failure).

Back to top

CAUSES & RISK FACTORS

Cause: It induces renin secretion that causes the angiotensin conversion, causing aldosterone release and then water retention and potassium depletion.

Back to top

DIAGNOSIS

Techniques have been developed to diagnose renal hypertension using digital image processing of radiographs. Treatment may involve angioplasty and stenting of the renal arteries. The syndrome may be related to other diseases of the epithelium.

Suggestive clinical features include onset of hypertension less than 30 or greater 50 years of age, abdominal or femoral bruits, hypokalemic alkalosis, moderate to severe retinopathy, acute onset of hypertension or malignant hypertension, and hypertension resistant to medical therapy.

The "gold standard" in diagnosis of renal artery stenosis is conventional arteriography. Magnetic resonance angiography (MRA) is used in many centers, especially among patients with renal insufficiency at higher risk for contrast nephropathy. MRA may overestimate the severity of stenosis relative to angiography. In patients with normal renal function and hypertension, the captopril (or enalaprilat) renogram may be used. Lateralization of renal function [accentuation of the difference between affected and unaffected (or "less affected") sides] is suggestive of significant vascular disease. Test results may be falsely negative in the presence of bilateral disease.

Back to top

TREATMENT OPTIONS

Renal hypoperfusion activates renin-angiotensin-aldosterone (RAA) axis; ACE inhibitors and angiotensin II receptor blocker classes of antihypertensives are contraindicated as they might compromise the renal function especially if the stenosis is bilateral. Nitroprusside, labetalol, or calcium antagonists are generally effective in lowering blood pressure acutely, although inhibitors of the RAA axis [e.g., ACE inhibitors, angiotensin II receptor blockers (ARBs)] are most effective long-term treatment, if disease is not bilateral.

Surgical revascularization appears to be superior for ostial lesions characteristic of atherosclerosis. The relative efficacy of surgery compared with angioplasty (especially with stenting) for fibromuscular dysplasia or for non-occlusive, non-ostial atherosclerotic disease is unclear. Angioplasty (with or without stenting) tends to be temporarily effective for some cases. However, as of early 2011, six randomized controlled trials have failed to demonstrate any real benefit in blood pressure control or preservation of renal function when using endovascular (angioplasty or stenting) procedures compared to medical therapy alone. ACE inhibitors or ARBs are ideal agents for hypertension associated with renal artery stenosis, except in patients with bilateral disease (see "Ischemic Nephropathy" below) or disease in a solitary kidney (including an allograft).

Back to top

 

Westchester Medical Center
100 Woods Road
Valhalla, NY 10595
914.493.7000
   
       
Hawthorne
19 Bradhurst Avenue, Suite 3750
Hawthorne, NY 10532
914.909.6835
    Mount Kisco
103 South Bedford Road, Suite 207
Mount Kisco, NY 10549
914.241.3204
       
New Windsor Division
575 Hudson Valley Avenue, Suite 200
New Windsor, NY 12553
845.561.2773
    White Plains
15 North Broadway
White Plains, NY 10601
914.593.1234

Vascular Surgery and Laser Vein Center

Please contact us at 877.WMC.VEIN or 877.962.8346.

Babu, Sateesh
Babu, Sateesh
Chief, Vascular Surgery
Vascular Surgery
Laskowski, Igor
Laskowski, Igor
Chief, Endovascular Surgery
Vascular Surgery
Carroll, Francis X.
Thoracic Surgery
Vascular Surgery
Goyal, Arun
Vascular Surgery
Mateo, Romeo B.
Vascular Surgery
Shah, Pravin M.
Vascular Surgery
Your Name:
Your Email:
Recipient Email:
Your Comments:
Word Verification:
CAPTCHA