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Hyperlipidemia

Hyperlipidemia, hyperlipoproteinemia, or hyperlipidaemia (British English) is the condition of abnormally elevated levels of any or all lipids and/or lipoproteins in the blood. It is the most common form of dyslipidemia (which also includes any decreased lipid levels).

Lipids (fat-soluble molecules) are transported in a protein capsule, and the size of that capsule, or lipoprotein, determines its density. The lipoprotein density and type of apolipoproteins it contains determines the fate of the particle and its influence on metabolism.

Hyperlipidemias are divided in primary and secondary subtypes. Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. Lipid and lipoprotein abnormalities are common in the general population, and are regarded as a modifiable risk factor for cardiovascular disease due to their influence on atherosclerosis. In addition, some forms may predispose to acute pancreatitis.

TREATMENT OPTIONS

For treatment of type II, dietary modification is the initial approach but many patients require treatment with statins (HMG-CoA reductase inhibitors) to reduce cardiovascular risk. If the triglyceride level is markedly raised, fibrates may be preferable due to their beneficial effects. Combination treatment of statins and fibrates, while highly effective, causes a markedly increased risk of myopathy and rhabdomyolysis and is therefore only done under close supervision. Other agents commonly added to statins are ezetimibe, niacin and bile acid sequestrants. Dietary supplementation with fish oil is also used to reduce elevated triglycerides, with the greatest effect occurring in patients with the greatest severity. There is some evidence for benefit of plant sterol-containing products and ω3-fatty acids.

Westchester Medical Center
100 Woods Road
Valhalla, NY 10595
914.493.7000
   
       
Hawthorne
19 Bradhurst Avenue, Suite 3750
Hawthorne, NY 10532
914.909.6835
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103 South Bedford Road, Suite 207
Mount Kisco, NY 10549
914.241.3204
       
New Windsor Division
575 Hudson Valley Avenue, Suite 200
New Windsor, NY 12553
845.561.2773
    White Plains
15 North Broadway
White Plains, NY 10601
914.593.1234

Vascular Surgery and Laser Vein Center

Please contact us at 877.WMC.VEIN or 877.962.8346.

Babu, Sateesh
Babu, Sateesh
Chief, Vascular Surgery
Vascular Surgery
Laskowski, Igor
Laskowski, Igor
Chief, Endovascular Surgery
Vascular Surgery
Carroll, Francis X.
Thoracic Surgery
Vascular Surgery
Goyal, Arun
Vascular Surgery
Mateo, Romeo B.
Vascular Surgery
Shah, Pravin M.
Vascular Surgery
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